Figure 3. Differential effects of synthetic B1R and B2R agonists on tumor and tissue uptake of the chemotherapy drug carboplatin and the contrast agent Gd-DTPA. Direct measures of drug concentration (ng/g of wet tissue) by ICP-MS in three different tissue extracts (tumor, tumor periphery and contralateral) from the brains of F98 glioma-bearing Fischer rats were made following intra-arterial (internal carotid) injections of Gd-DTPA (Gd) (143 mM i.v.) and carboplatin (Pt) (20 mg/kg) with various agonists (250 nmol/kg) or saline (CTRL) in a single 1-ml infusion over 10 min. Five minutes after the end of the infusion, rats were euthanized and the brain rapidly removed, dissected into regions, and prepared for ICP-MS analysis. Differences were examined by the Student unpaired t test, considering P < 0.05 siginificant. General methods as in Côté et al.⁶