Table 1.

Minimum Inhibition Concentration (MIC) Values of Disubstituted Benzene Derivatives Based on Sir2p Inhibition Against the Yeast Strain DMY2844

Structural group		R1	R2	Location	MIC (μM)
A	5	(CH3)2N−	−COOH	p	200
	6	(CH3)2N−	−COOH	m	NAa
	7	(CH3)2N−	−COOH	o	NA
	8	(CH3)2N−	none		NA
	9	none	−COOH		NA
B	10	CH3NH−	−COOH	p	400
	11	NH2−	−COOH	p	800
C	12	(CH3)2N−	−COOCH3	p	400
	13	(CH3)2N−	−CONH2	p	NA
	14	(CH3)2N−	−SO3H	p	NA
	15	(CH3)2N−	−Br	p	NA
	16	(CH3)2N−	NO2	p	NA
D	17	CH3−	−COOH	p	800
	18	(CH3)2CH−	−COOH	p	200
E	19	(CH3)3N+−	−COO-	p	NA
	20	(CH3)3C−	−COOH	p	50

^aNot active at 800 μM