Table 1.
Degrees of histopathological injuries of kidney sections in rats treated with GM, PTU and GM co-administration with PTU (n=28)
| Parameters | Control | GM | PTU | GM+PTU |
|---|---|---|---|---|
| ATN | 0 | 3 | 0 | 4 |
| Glomerular atrophy | 0 | 3 | 0 | 2 |
| Hyaline casts in tubular lumen | 0 | 2 | 0 | 4 |
| Interstitial nephritis | 0 | 2 | 2 | 0 |
| Hyperemia | 0 | 2 | 1 | 0 |
| Lipofuscin pigments | 0 | 0 | 2 | 0 |
| Infiltration of inflammatory cells | 0 | 2 | 1 | 2 |
| Interstitial fibrosis | 0 | 0 | 1 | 1 |
PTU (10 mg/kg for 18 d) was injected intraperitoneally (IP) alone or in combination with GM (80 mg/kg, IP for 8 d). Control rats received saline. GM= gentamicin, PTU= propylthiouracil, ATN= acute tubular necrosis 0 = normal, 1= mild, 2=moderate, 3= severe, 4 = very severe