Table 1.
Conservation of five known functional lncRNAs.
lncRNA | most distant species from human where conservation was detected | conservation type (genomic, transcription, gene structure, RNA secondary structure) | reference |
SRA | marsupials and monotremes | genomic sequence; and RNA secondary structure | 24 |
GAS5 | mouse | genomic sequence; transcription; and RNA secondary structure | 35 |
XIST | eutherian mammals | genomic sequence; transcription; and gene structure | 52 |
HOTAIR | mouse | genomic sequence; transcription (but gene structure is different) | 59 |
MALAT-1 | fish | genomic sequence at 3’end | 65 |