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. Author manuscript; available in PMC: 2014 Dec 19.
Published in final edited form as: Chem Biol. 2013 Dec 12;20(12):1536–1546. doi: 10.1016/j.chembiol.2013.11.005

Figure 7.

Figure 7

BHQ-O-5HT disrupts LR patterning in Xenopus laevis embryos. (a) Position of three organs (heart, red arrow; stomach, yellow arrow; gall bladder, green arrow) in wild type tadpoles and tadpoles with LR patterning defects. Single-cell embryos were soaked (b) or injected (c) with 5-HT or BHQ-O-5HT and LR defects were assessed following uncaging. (d) Temporal assessment of BHQ-O-5HT uncaging indicates a critical period for the effect of 5-HT on LR patterning. Treatment with BHQ-OH ruled out effects of the PPG and the uncaging light treatment in LR defects. * p < 0.01 relative to controls, chi-square test.