Table 2.
Parameter | Formulation’s code |
|||||||||
---|---|---|---|---|---|---|---|---|---|---|
F1 | F2 | F3 | F4 | F5 | F6 | F7 | F8 | F9 | F10 | |
Hardness kg/cm2 | 1.83 ± 0.29 | 2.33 ± 0.49 | 3.00 ± 0.03 | 3.19 ± 0.30 | 2.36 ± 0.26 | 2.99 ± 0.68 | 2.49 ± 0.31 | 3.39 ± 0.35 | 3.41 ± 0.30 | 3.42 ± 0.32 |
Weight variation | 298 ± 1.60 | 299 ± 0.91 | 298 ± 1.40 | 300 ± 0.69 | 296 ± 1.90 | 297 ± 1.90 | 300 ± 1.80 | 300 ± 1.60 | 549 ± 1.80 | 798 ± 1.90 |
% F | 0.68 | 0.85 | 0.92 | 0.99 | 0.81 | 0.78 | 0.75 | 0.81 | 0.83 | 0.83 |
WT (sec) | 57.33 ± 1.52 | 46.00 ± 2.94 | 42.33 ± 1.69 | 38.00 ± 1.20 | 43.00 ± 0.99 | 32.50 ± 0.83 | 32.67 ± 1.05 | 27.33 ± 0.76 | 30.32 ± 0.89 | 29.91 ± 0.97 |
DT (sec) | 56 ± 0.82 | 44.33 ± 1.12 | 40.67 ± 0.98 | 37.66 ± 1.23 | 40.33 ± 1.03 | 38.33 ± 1.23 | 28.33 ± 1.99 | 21.66 ± 2.01 | 28.79 ± 1.39 | 21.67 ± 0.87 |
(θ°) | 45.48 | 39.82 | 37.34 | 35.12 | 34.87 | 32.53 | 33.74 | 30.13 | 31.5 | 30.1° |
CI | 21.18 | 18.62 | 18.95 | 19.81 | 20.46 | 19.24 | 20.48 | 18.71 | 18.44 | 17.88 |
HR | 1.239 | 1.229 | 1.234 | 1.247 | 1.251 | 1.238 | 1.274 | 1.230 | 1.212 | 1.231 |
% F = % Friability, WT = wetting time, DT = disintegration time, CI = Carr’s Index, HR = Hausner Ratio.