Fig. 5.

Role of nutraceutical antioxidants in the treatment of chemotherapy induced peripheral neuropathy (CIPN): nutraceutical antioxidants exhibited significant neuroprotection towards chemotherapy induced neurotoxicity by decreasing cellular oxidative stress through their inherent free radical scavenging property (glutathione [39], [40], melatonin [41], n-acetyl cysteine [42], ω-3 fatty acids [43], α-lipoic acid [30] etc) and indirectly by increasing whole blood concentrations of antioxidant enzymes (glutamine [44], n-acetyl cysteine [42]), normalizing mitochondrial functions (n-acetyl carnitine [29], α-lipoic acid [30]), attenuating the production of proinflammatory mediators (ω-3 fatty acids [43]) etc. Totally these nutraceutical antioxidants normalize the cellular functions, rescue mitochondrial impairment, inhibit neuronal inflammation, apoptosis and therefore diminish the sensory nerve degeneration [2], [45].