Table 1.
Top ranking genes in EGFR PPI subnetwork by various centrality measures.
| Gene | cd | cb | ce | c2s | c3s | crd | crb | cre | c2rs | c3rs |
|---|---|---|---|---|---|---|---|---|---|---|
| AKT1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| EGF | 2 | 3 | 2 | 2 | 2 | 2 | 3 | 2 | 2 | 2 |
| EGFR | 3 | 2 | 3 | 3 | 3 | 3 | 2 | 3 | 3 | 3 |
| GRB2 | 4 | 5 | 4 | 4 | 4 | 4 | 5 | 5 | 5 | 4 |
| MAPK1 | 5 | 4 | 5 | 5 | 5 | 5 | 4 | 4 | 4 | 5 |
| RAC1 | 6 | 7 | 6 | 6 | 6 | 6 | 8 | 6 | 6 | 6 |
| CDC42 | 7 | 6 | 7 | 7 | 7 | 7 | 6 | 8 | 7 | 7 |
| MAPK3 | 8 | 10 | 8 | 8 | 8 | 8 | 10 | 7 | 8 | 8 |
| STAT3 | 9 | 9 | 9 | 9 | 9 | 9 | 9 | 9 | ||
| ERBB2 | 10 | 8 | 10 | 10 | 10 | 7 | 10 | 10 | ||
| FOS | 9 | 9 | ||||||||
| PTEN | 10 | 10 | ||||||||
| cd | 0.92 | 0.97 | 1 | 1 | 1 | 0.9 | 0.96 | 0.99 | 1 | |
| cb | 0.87 | 0.92 | 0.92 | 0.92 | 0.99 | 0.85 | 0.93 | 0.92 | ||
| ce | 0.97 | 0.97 | 0.97 | 0.83 | 0.99 | 0.97 | 0.97 | |||
| c2s | 1 | 1 | 0.9 | 0.96 | 0.99 | 1 | ||||
| c3s | 1 | 0.9 | 0.96 | 0.99 | 1 | |||||
| crd | 0.9 | 0.96 | 0.99 | 1 | ||||||
| crb | 0.8 | 0.9 | 0.9 | |||||||
| cre | 0.97 | 0.96 | ||||||||
| cr2s | 0.99 |
cd, degree centrality; cb, node betweenness; ce, eigenvector centrality; c2s, c3s, spectral gap centrality h = 2, 3. cr{d,b,e,s},c{2,3}rs, node ranking are obtained by consecutively removing the top ranked nodes. The bottom matrix is Spearman's rank correlation coefficients.