Table 2.
Top ranking genes in EGFR pathway by various centrality measures.
| Gene | cd | cb | ce | c2s | c3s | crd | crb | cre | c2rs | c3rs |
|---|---|---|---|---|---|---|---|---|---|---|
| SRC | 1 | 2 | 5 | 1 | 2 | 3 | 2 | 5 | ||
| STAT3 | 2 | 1 | 3 | 2 | 2 | 1 | 2 | |||
| EGFR | 4 | 3 | 1 | 6 | 7 | 7 | 1 | 10 | ||
| HRAS | 6 | 3 | 8 | 5 | 9 | 4 | 6 | |||
| MAPK1 | 7 | 9 | 4 | 7 | 6 | 6 | 3 | 4 | ||
| MAPK3 | 8 | 9 | 9 | 2 | ||||||
| GRB2 | 9 | 1 | 7 | 1 | 8 | 1 | 5 | 5 | 1 | |
| MAPK7 | 10 | 10 | 8 | |||||||
| SOS1 | 2 | 6 | 3 | |||||||
| RAF1 | 4 | 5 | 3 | 4 | ||||||
| REPS2 | 5 | |||||||||
| ASAP1 | 6 | 4 | ||||||||
| MAP2K1 | 7 | 4 | 3 | |||||||
| MAP2K2 | 10 | 6 | ||||||||
| STAT1 | 2 | |||||||||
| JAK2 | 4 | |||||||||
| JAK1 | 5 | |||||||||
| PIAS3 | 6 | |||||||||
| COX2 | 7 | |||||||||
| GRIM19 | 8 | |||||||||
| PLCG1 | 9 | 8 | 9 | |||||||
| GAB1 | 8 | |||||||||
| PLD1 | 10 | |||||||||
| CBLC | 9 | |||||||||
| MAPK8 | 10 | |||||||||
| SH3KBP1 | 7 | 7 | ||||||||
| JUN | 9 | |||||||||
| JUND | 10 | |||||||||
| cd | 0.34 | −0.27 | 0.76 | 0.68 | 0.87 | 0.53 | 0.76 | 0.66 | 0.69 | |
| cb | −0.35 | 0.65 | 0.78 | 0.3 | 0.44 | 0.26 | 0.4 | 0.39 | ||
| ce | −0.29 | −0.25 | −0.19 | −0.31 | −0.24 | −0.16 | −0.21 | |||
| c2s | 0.81 | 0.53 | 0.5 | 0.49 | 0.71 | 0.51 | ||||
| c3s | 0.65 | 0.44 | 0.49 | 0.48 | 0.7 | |||||
| crd | 0.65 | 0.8 | 0.48 | 0.79 | ||||||
| crb | 0.6 | 0.54 | 0.45 | |||||||
| cre | 0.35 | 0.5 | ||||||||
| cr2s | 0.51 |
Spearman's rank correlation coefficients are computed on genes in the table with their actual rankings (ranking > 10 not shown). Nodes that do not directly correspond to genes are omitted.