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. 2014 Feb 3;5:12. doi: 10.3389/fgene.2014.00012

Table 6.

High betweenness edges in MAPK pathway (KEGG).

Rank eb (Edge) Path erb (Edge) Path
1 Raf1–MEK2 Classical MAPK Raf1–MEK2 Classical MAPK
2 Ras–Raf1 Classical MAPK ASK1–MKK3 p38 MAPK
3 MEKK1–MEK2 MKK4–JNK JNK MAPK
4 MEK2–ERK Classical MAPK MEKK1–MEK2
5 SOS–Ras Classical MAPK MKK4–MKK7 JNK MAPK