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Effect of adiponectin and IL-1β on the production of VEGF, MMP-1 and MMP-13 in (a) endothelial cells and (b) osteoblasts. The cells were treated with adiponectin or IL-1β for 24 h. The culture supernatants were analyzed for VEGF, MMP-1 and MMP-13 by ELISA. The data shown are representative of three independent experiments and similar results were obtained from all three. Values are expressed as mean±s.e.m. *P<0.05 vs the untreated group, #P<0.05 vs the IL-1β-treated group.
