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. Author manuscript; available in PMC: 2014 Feb 3.
Published in final edited form as: JAMA. 2009 Oct 7;302(13):1429–1436. doi: 10.1001/jama.2009.1420

Figure 1. Kaplan-Meier Estimates of Time to Recurrence, Event-Free Survival, and Disease-Free Survival.

Figure 1

EM indicates extensive metabolism (ie, patients with 2 functional CYP2D6 alleles, including patients with ultrarapid metabolism); hetEM/IM, patients with intermediate or 1 poor metabolism allele; PM, patients homozygous for poor metabolism alleles. The curves were truncated at 15 years after diagnosis and calculations included overall time (median follow-up, 6.3 years). Percentage differences vs unstratified are as follows: for time to recurrence, at 9 years, 3.4% for EM and 10.7% for PM, and at 15 years, 7.2% for EM and 19.0% for PM; for event-free survival, at 9 years, 3.3% for EM and 6.4% for PM, and at 15 years, 5.7% for EM and 10.9% for PM; and for disease-free survival, at 9 years, 2.3% for EM and 4.5% for PM, and at 15 years, 6.4% for EM and 17.9% for PM.