Table 5.
Pharmacokinetic parameters for Tonact, Aten, and bilayer tablets (containing 10 mg of atorvastatin and 50 mg of atenolol) after oral administration to healthy rabbit (n = 3).
| Parametera | Tablet | |||
|---|---|---|---|---|
| Tonact | Aten | Bilayer tablet | ||
| Atorvastatin | Atenolol | |||
| C max (µg mL−1) | 17.00 ± 4.47 | 27.53 ± 3.53 | 18.19 ± 5.10 | 26.55 ± 8.24 |
| T max (h) | 0.52 ± 0.34 | 3.11 ± 2.21 | 0.54 ± 0.29 | 3.08 ± 1.89 |
| AUC0–∞ (µg h mL−1) | 81.04 ± 22.29 | 342.65 ± 62.82 | 106.47 ± 31.48 | 347.12 ± 74.67 |
| AUMC0–∞ (µg h2 mL−1) | 334.89 ± 79.35 | 2796.51 ± 52.50 | 780.37 ± 102.84 | 2847.31 ± 96.49 |
| MRT (h) | 5.29 ± 0.48 | 8.16 ± 0.15 | 7.33 ± 0.62 | 8.20 ± 0.94 |
| t 1/2 (h) | 3.04 ± 0.41 | 7.54 ± 0.64 | 3.31 ± 0.24 | 9.90 ± 0.55 |
| K el (h−1) | 0.23 ± 0.01 | 0.10 ± 0.01 | 0.21 ± 0.03 | 0.07 ± 0.01 |
a T max: time to reach plasma concentration (C max); AUC: area under plasma concentration-time curve; AUMC: area under the first momentum plasma concentration-time curve; MRT: mean residence time; t 1/2: plasma half-life of drug; K el: elimination rate constant.