Figure 2.

Schematic representation of the systems pharmacology model. Arrows represent binding, synthesis, degradation, and transport processes. XEA (X = A, O, P, and S) relates to the various ethanolamides (A – anandamide, O – oleoylethanolamide, P – palmitoylethanolamide, and S – stearoylethanolamide). The terms CB1 and CB1–AEA designate cannabinoid receptor CB1 and its complex with anandamide, respectively. Empty circles indicate fatty acid amide hydrolase (FAAH)-catalyzed XEA degradation and PF-04457845 inhibition of FAAH. The question mark shows the FAAH-independent clearance process. BBB, blood–brain barrier.