Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Initial simulations related to example clinical data. The observed plateau in anandamide (AEA) response cannot be adequately described without evoking an additional fatty acid amide hydrolase (FAAH)-independent clearance process. The open circles are mean clinical plasma AEA data, following single oral administration of 10 mg of PF-04457845. The dotted line shows simulations without a FAAH-independent clearance and the solid line shows the results after including it.
