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Simulations of the model compared with clinical data assuming fatty acid amide hydrolase (FAAH)-independent clearance. (a,b) Time dependence of FAAH activity and (c,d) concentrations of ethanolamides after single oral administration of (a,c) 1 mg and (b,d) 10 mg of PF-04457845. AEA, OEA, PEA, and LEA: anandamide, oleoylethanolamide, palmitoylethanolamide, and stearoylethanolamide, respectively. Dots indicate clinically measured data, and solid curves are simulation results.
