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. 2014 Jan 15;3(1):e91. doi: 10.1038/psp.2013.72

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Copyright © 2014 ASCPT

CPT: Pharmacometrics and Systems Pharmacology is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/

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Sensitivity analysis plot showing the integral of the sensitivity for each parameter in the model, calculated as described in the Methods section without normalization. kdeg_FAAH (the degradation rate constant for FAAH), p_A (the precursor substrate concentration for N-arachidonoyl phosphatidylethanolamine (NAPE) synthesis), b_FAAH_brain (brain FAAH concentration), a-NAT_A (the brain N-acyltransferase catalyzing the synthesis of the anandamide (AEA) precursor N-arachidonoyl phosphatidylethanolamine from p_A), and Kp_b (the brain partition coefficient) are shown. FAAH, fatty acid amide hydrolase.