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DrugFEATURE evaluated two sites in RUNX1/CBF-β complex (1H9D): the DNA-recognition site (yellow) has a low druggability score (1.00) and the protein–protein interacting site (blue) between RUNX1 and CBF-β is highly druggable (score 2.76). Druggable microenvironments (blue spheres in the right panel) are centered on the functional centers in chain B residue 53E and chain A residue 153F, 121T, 120A, 117 L, and 116E. CBF, core DNA-binding factor.
