Figure 2.

Simulations based on the standard dosing scheme in the clinical trial described in Bruno et al.¹⁸: 4-mg/kg loading dose and then 2-mg/kg dose weekly by an intravenous infusion of 90 min for each dose. Panels (a), (b), and (c) respectively show the concentrations of drug and complex in the plasma, the interstitial space, and the fraction of the occupied receptor at the membrane, in the interstitial space, and in plasma. Simulations were performed with a shedding rate (k_sh,p) of 0.0023 h⁻¹, corresponding to an initial level of ECD^HER2 in plasma of 14.6 ng/ml. ECD, ectodomain.