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. Author manuscript; available in PMC: 2014 Feb 3.
Published in final edited form as: J Biol Chem. 2007 May 1;282(25):18100–18107. doi: 10.1074/jbc.M702906200

FIGURE 2. Three behavioral experiments in which rats are shocked but do not exhibit contextual learning.

FIGURE 2

A, rats placed into a contextual training chamber, shocked immediately, and removed to the home cage immediately thereafter (Shock/Remove, n = 8) show dramatically reduced contextual fear memory measured 24 h after training compared with traditionally fear-conditioned rats (Fear Conditioned, n = 6). Contextual fear memory of the Shock/Remove group was not significantly different from sham-trained rats that did not receive footshock during training (No Shock, n = 8). B, rats pre-exposed to the training chamber for 16 h before training (Latent Inhibition, n = 7) showed dramatically reduced contextual fear memory measured 24 h after training compared with traditionally fear-conditioned rats that were pre-exposed to a completely different novel context (Shock, n = 8). Contextual fear memory of the Latent Inhibition group was similar in magnitude to sham-trained animals that did not receive footshock (No Shock, n = 8). C, NMDA receptor inhibition with MK-801 30 min before training significantly decreased contextual fear memory measured 24 h after training in a dose-dependent manner.