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. Author manuscript; available in PMC: 2014 Feb 3.
Published in final edited form as: J Am Acad Dermatol. 2013 Jul 18;69(4):570–577. doi: 10.1016/j.jaad.2013.05.019

Fig 4.

Fig 4

Association of elevated serine protease activity (SPA) with disease activity in rosacea. Tape-strip samples from patients with rosacea (n = 49) and facial skin of healthy patients (n = 10) were obtained, and SPA measured after normalization to total protein. A, Individual measurements of SPA are shown from separate sites on face. Data are clustered into patients with rosacea who had high mean baseline SPA value of >100,000 RFU/μg (high baseline), mean value <100,000 (low baseline), or healthy patients. Wide range of individual site SPA measurements is seen in high baseline group. Healthy patients have significantly lower SPA measurement than those with rosacea, *P <.001. B, Clinical assessment scores were obtained concurrently with tape-strip samples to evaluate correlation between SPA and disease activity. Patients with Clinician Erythema Assessment (CEA) scores designated as “severe” had significantly higher SPA (n = 21) than those with moderate or mild disease activity (n = 28). *P <.05. P values obtained by Student t test in GraphPad Prism (GraphPad Software Inc, La Jolla, CA).