Table 2.

Maturation of hiPSC-CM ion current gene expression

Current	Cell Line(s) (all from fibroblasts)	Gene	Gene product	Result	Reference
INa	dermal 201B7	SCN5A	Nav1.5	Expressed in differentiated hiPSC-CMs but not undifferentiated cells	(Tanaka et al., 2009)
ICaL	dermal 201B7	CACNA1C	Cav1.2	Expressed in differentiated hiPSC-CMs but not undifferentiated cells	(Tanaka et al., 2009)
	fetal IMR90			Increased approximately 2-fold in response to cyclic stress	(Tulloch et al., 2011)
	hFib2			Significantly upregulated over first 21 days of differentiation	(Zwi et al., 2009)
	foreskin	CACNA1D	Cav1.3	Significantly upregulated over first 21 days of differentiation	(Mehta et al., 2011)
	hFib2				(Zwi et al., 2009)
IKs	hFib2	KCNQ1	Kv7.1	Expressed in differentiated hiPSC-CMs but not undifferentiated cells	(Zwi et al., 2009)
IKr	dermal 201B7	KCNH2 (HERG)	Kv11.1	Expressed in differentiated hiPSC-CMs but not undifferentiated cells	(Tanaka et al., 2009)
	foreskin			Significantly upregulated over first 21 days of differentiation	(Mehta et al., 2011)
	hFib2				(Zwi et al., 2009)
If	foreskin	HCN2		Significantly upregulated over first 21 days of differentiation	(Mehta et al., 2011)
	hFib2				(Zwi et al., 2009)
Ito1	dermal 201B7	KCND3	Kv4.3	Present but no maturation effects were reported.	(Yokoo et al., 2009)
IK1	dermal 201B7	KCNJ2	Kir2.1	Present but no maturation effects were reported.	(Yokoo et al., 2009)