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. Author manuscript; available in PMC: 2015 Feb 20.
Published in final edited form as: J Mol Biol. 2013 Nov 28;426(4):816–829. doi: 10.1016/j.jmb.2013.11.019

Figure 2.

Figure 2

Comparative cellular activities of L- and D-polyQ versions of PKKKRKVGGQ25KK amyloid fibrils. (a) Percent of WT PC12 cells undergoing lytic death (LDH release) after 24 hrs exposure to different concentrations of L- or D-polyQ versions of PKKKRKVGGQ25KK amyloid; (b) percent of Htt-exon1-Q25-EGFP cells treated with 2.5 μM (monomer equivalent) of PKKKRKVGGQ25Ccy5KK amyloid that develop green puncta (see Figure 3) at different growth times. Values in a and b are from three independent experiments and are expressed as mean ± SEM (**, p < 0.01, ***, p < 0.001).