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. Author manuscript; available in PMC: 2014 Dec 9.
Published in final edited form as: Chemistry. 2013 Nov 6;19(50):17043–17053. doi: 10.1002/chem.201301659

Figure 1.

Figure 1

Structures and proposed mechanism of inhibition of histidine-containing proteins by CoIII Schiff base complexes. (A) CoIII Schiff base complexes contain a CoIII metal center stabilized by a tetradentate acetylacetonatoethylenediimine ligand (acacen). The axial positions bear labile ligands that are believed to undergo dissociative ligand exchange allowing coordination of imidazole side chains of His residues. (B) CoIII Schiff base complexes used in the present studies, [Co(acacen)(NH3)2]+ (1) and [Co(acacen)(4MeIm)2]+ (2). (C) Naming scheme for histidine protons. Focus is placed on the methine protons of the imidazole referred to as H2 and H5.