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. Author manuscript; available in PMC: 2014 Feb 3.
Published in final edited form as: Clin Cancer Res. 2012 Nov 12;19(1):73–84. doi: 10.1158/1078-0432.CCR-12-2952

Figure 4. Functional significance and tumor suppressor role for miR-34b in PCa.

Figure 4

A) Proliferation and colony fromation of PC3 and LNCaP cells after miR-34b transfection was significantly reduced compared to cont-miR. B) Cell cycle analysis showing an increase in the G0/G1 phase and a decrease in S-phase cell population with miR-34b. C) Apoptosis assay showing induction of apoptosis by miR-34b. D) Luciferase reporter assay showing miR-34b directly targets proliferative marker AKT and Western blot showing downregulation of downstream Akt pathway genes at the protein level.