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. Author manuscript; available in PMC: 2014 Oct 1.
Published in final edited form as: J Rheumatol. 2013 Aug 15;40(10):1669–1676. doi: 10.3899/jrheum.121493

Table 5.

Fracture risk (Hazard Ratio [HR]) for any first fragility fracture or first major osteoporotic fracture (fragility fracture at proximal femur, thoracic/lumbar vertebrae, distal radius, or proximal humerus) among women and men with RA from Olmsted County, Minnesota, stratified by age at diagnosis, and relative to their matched non-RA pair.

Sex and
Age Groups
Subjects N Fragility Fractures Major Osteoporotic Fractures
N Per 1000 P-Y HR (95% CI) N Per 1000 P-Y HR (95% CI)
All Women RA 822 282 30.8 1.63 (1.36–1.96) 212 23.2 1.78 (1.43–2.21)
Non-RA 822 193 21.1 129 14.1
Age ≥50 RA 514 201 40.0 1.43 (1.16–1.77) 158 31.5 1.46 (1.15–1.86)
Non-RA 514 151 30.1 113 22.5
Age < 50 RA 308 81 19.6 2.34 (1.61–3.42) 54 13.1 4.05 (2.31–7.10)
Non-RA 308 42 10.2 16 3.9
Age < 50* RA 308 32 16.3 1.95 (1.08–3.51) 14 7.1 4.80 (1.38–16.73)
Non-RA 308 17 8.7 3 1.5
All Men RA 349 88 24.2 1.40 (1.02–1.93) 68 18.7 1.65 (1.13–2.42)
Non-RA 349 65 17.9 43 11.8
Age ≥ 50 RA 239 63 30.9 1.34 (0.92–1.94) 51 25.0 1.77 (1.13–2.77)
Non-RA 239 50 24.5 31 15.2
Age < 50 RA 110 25 15.7 1.74 (0.91–3.30) 17 10.7 1.49 (0.71–3.12)
Non-RA 110 15 9.4 12 7.5
Age < 50* RA 110 6 8.1 0.82 (0.28–2.45) 3 4.0 0.75 (0.17–3.35)
Non-RA 110 7 9.4 4 5.4
*

Follow-up ended at age ≤ 50 years

Note that the number of fractures observed may differ from those reported in Table 2 or 3 because only the first fracture of each type per subject was counted in these analysis.