Table 5.

Fracture risk (Hazard Ratio [HR]) for any first fragility fracture or first major osteoporotic fracture (fragility fracture at proximal femur, thoracic/lumbar vertebrae, distal radius, or proximal humerus) among women and men with RA from Olmsted County, Minnesota, stratified by age at diagnosis, and relative to their matched non-RA pair.

Sex and Age Groups	Subjects	N	Fragility Fractures			Major Osteoporotic Fractures
			N	Per 1000 P-Y	HR (95% CI)	N	Per 1000 P-Y	HR (95% CI)
All Women	RA	822	282	30.8	1.63 (1.36–1.96)	212	23.2	1.78 (1.43–2.21)
	Non-RA	822	193	21.1	–	129	14.1	–
Age ≥50	RA	514	201	40.0	1.43 (1.16–1.77)	158	31.5	1.46 (1.15–1.86)
	Non-RA	514	151	30.1	–	113	22.5	–
Age < 50	RA	308	81	19.6	2.34 (1.61–3.42)	54	13.1	4.05 (2.31–7.10)
	Non-RA	308	42	10.2	–	16	3.9	–
Age < 50*	RA	308	32	16.3	1.95 (1.08–3.51)	14	7.1	4.80 (1.38–16.73)
	Non-RA	308	17	8.7	–	3	1.5	–
All Men	RA	349	88	24.2	1.40 (1.02–1.93)	68	18.7	1.65 (1.13–2.42)
	Non-RA	349	65	17.9	–	43	11.8	–
Age ≥ 50	RA	239	63	30.9	1.34 (0.92–1.94)	51	25.0	1.77 (1.13–2.77)
	Non-RA	239	50	24.5	–	31	15.2	–
Age < 50	RA	110	25	15.7	1.74 (0.91–3.30)	17	10.7	1.49 (0.71–3.12)
	Non-RA	110	15	9.4	–	12	7.5	–
Age < 50*	RA	110	6	8.1	0.82 (0.28–2.45)	3	4.0	0.75 (0.17–3.35)
	Non-RA	110	7	9.4	–	4	5.4	–

^*Follow-up ended at age ≤ 50 years

Note that the number of fractures observed may differ from those reported in Table 2 or 3 because only the first fracture of each type per subject was counted in these analysis.