Table 2.

Baseline and time-varying correlates of apolipoproteins

Variable	Apo A1		Apo B		Apo B/apo A1
	Coefficient (95% CI)	P-value	Coefficient (95% CI)	P-value	Coefficient (95% CI)	P-value
Fixed covariates
Age, years	0.52 (0.30, 0.74)	<0.0001	−0.26 (−0.49, −0.03)	0.02	−0.007 (−0.01, <0.01)	0.0006
Age2	–	–	−0.02 (−0.03, <0.01)	0.009	−0.0002 (>−0.01, <−0.01)	0.01
BMI, kg/m2	−0.60 (−1.13, −0.17)	0.01	0.48 (0.13, 0.84)	0.007	0.01 (0.01, 0.01)	<0.0001
Sex, female	18.07 (11.10, 25.04)	<0.0001	1.79 (−6.09, 9.67)	0.66	−0.10 (−0.20, <0.01)	0.05
Race, white	−6.32 (−12.80, 0.15)	0.06	3.50 (−3.99, 10.98)	0.36	0.09 (≥0.01, 0.18)	0.06
Modality/access
HD, AVF or AVG	Reference		Reference		Reference
HD, catheter	−6.15 (−14.74, 2.44)	0.16	−2.93 (−9.39, 3.52)	0.37	0.003 (−0.10, 0.10)	0.98
PD	−1.83 (−15.96, 12.30)	0.80	20.38 (1.94, 38.82)	0.03	0.20 (−0.04, 0.44)	0.11
Diabetes	−10.83 (−20.22, −1.44)	0.02	−6.70 (−14.76, 1.37)	0.10	−0.04 (−0.16, 0.08)	0.47
Atherosclerosis	−8.49 (−16.32, −0.65)	0.03	−5.20 (−14.62, 4.22)	0.28	−0.01 (−0.14, 0.11)	0.88
CHF	−0.02 (−7.20, 7.17)	>0.99	1.69 (−5.11, 8.50)	0.63	0.05 (−0.04, 0.13)	0.31
Serum creatinine, mg/dL	−0.45 (−1.23, 0.32)	0.25	−0.76 (−1.15, −0.36)	0.0002	−0.005 (−0.01, <0.01)	0.05
Time and time-varying covariates	Change in apo A1		Change in apo B		Change in apo B/apo A1
Time, per quarter	−10.76 (−14.42, −7.10)	<0.0001	0.80 (0.01, 1.59)	0.05	0.11 (0.07, 0.14)	<0.001
Time2	2.81 (2.05, 3.57)	<0.0001	–	–	−0.03 (−0.03, −0.02)	<0.001
α1AG, mg/dL	−0.16 (−0.25, −0.08)	0.0003	0.03 (−0.05, 0.10)	0.44	0.001 (<0.01, <0.01)	0.03
Time*creatinine	0.35 (−0.07, 0.77)	0.10	–	–	−0.007 (−0.01, −0.002)	0.01
Time2*creatinine	−0.14 (−0.25, −0.02)	0.02	–	–	0.003 (−0.01, ≥0.01)	0.001

BMI, body mass index; HD, hemodialysis; AVF, arteriovenous fistula; AVG, arteriovenous graft; PD, peritoneal dialysis; CHF, congestive heart failure; α1AG, alpha 1 acid glycoprotein.