FIGURE 4:

Blockade of KCa3.1 improved renal injury in two STZ-induced diabetic models. Two STZ-induced diabetic mouse models are used in this study: wild-type KCa3.1+/+ and KCa3.1−/− mice, and secondly eNOS−/− mice treated with or without a selective inhibitor of KCa3.1 (TRAM34). Kidney function was assessed by measuring the 24-h urinary albumin excretion. The 24-h urinary albumin excretion is significantly reduced in both KCa3.1-deficient mice (A) and eNOS−/− mice treated with TRAM34 (B). Results are presented as means ± SEM. *P < 0.05 and **P < 0.01, n = 6–8.