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. 2013 Oct 28;29(2):313–324. doi: 10.1093/ndt/gft431

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© The Author 2013. Published by Oxford University Press on behalf of ERA-EDTA.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits noncommercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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FIGURE 7: — Blockade of KCa3.1 inhibited MMP2 and MMP9 expression in two STZ-induced diabetic models. Quantitative RT–PCR showed increased mRNA expression of MMP2 (A) and MMP9 (B) in the kidneys of diabetic KCa3.1+/+ mice compared with control mice but reduced in diabetic KCa3.1−/− kidneys (n = 8). Quantitative RT–PCR showed increased mRNA expression of MMP2 (C) and MMP9 (D) in the kidneys of eNOS−/− diabetic mice compared with control mice but reduced in diabetic kidneys treated with TRAM34 (n = 6). Results are presented as mean + SEM. *P < 0.05 and **P < 0.01.