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. Author manuscript; available in PMC: 2014 Feb 3.
Published in final edited form as: J Biol Chem. 2005 Oct 19;280(52):42655–42668. doi: 10.1074/jbc.M505910200

Figure 7. Analysis of the mechanisms of action of TUDCA and paraquat.

Figure 7

(A) Treatment with TUDCA does not protect against rotenone-induced toxicity in the Ced-3 knockout worm compared to the untreated group; (+) p<0.01. The Ced-3 knockout worms was less vulnerable to rotenone toxicity than the non-tg strain, but addition of TUDCA did not provide any additional protection; (*) p<0.01. (B) Treatment with DβHB did not protect the non-tg, K08E3.7 KO or A53T α-synuclein expressing strain against paraquat induced toxicity. (+) p<0.01 compared to untreated of the same strain. (C) Treatment with probucol partially protects against paraquat induced toxicity in the non-tg, K08E3.7 KO and A53T α-synuclein expressing strains; (#) p<0.01 compared to paraquat treated of the same strain. (+) p<0.01 compared to untreated of the same strain.