Table 3.

Cox proportional hazards regression for prediction of incident atrial fibrillation in HFpEF.

Variable	Univariable HR (95%CI)	p-value	Age and sex-adjusted HR (95%CI)	p-value
Age (per 10y)	1.30 (1.14–1.50)	<0.0001	-	-
Hypertension	1.51 (1.0–2.16)	0.019	1.41 (0.99–2.01)	0.054
Statin use	0.59 (0.37–0.90)	0.013	0.62 (0.39–0.95)	0.027
eGFR (per 10ml/min/1.73m²)	0.89 (0.82–0.96)	0.004	0.91 (0.83–0.99)	0.027
LAVI (per 10ml/m²)	1.33 (1.02–1.70)	0.033	1.30 (0.99–1.68)	0.059
e’ (per 0.01ms)	0.83 (0.69–0.98)	0.031	0.87 (0.72–1.05)	0.15
E/e’ ratio	1.05 (1.01–1.09)	0.012	1.04 (1.00–1.08)	0.036
CHADS₂	1.15 (1.01–1.31)	0.034	n/a^*	-
CHA₂DS₂-VASc	1.12 (1.02–1.24)	0.023	n/a^*	-

CI, confidence interval; eGFR, estimated glomerular filtration rate (Modified Diet in Renal Disease formula); HR, hazard ratio; LAVI, left atrial volume index.

Age is a component of the CHADS₂ score and age and sex are incorporated in the CHA₂DS2-VASc score²⁰.