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. Author manuscript; available in PMC: 2014 Feb 3.
Published in final edited form as: Immunity. 2012 Jul 26;37(2):235–248. doi: 10.1016/j.immuni.2012.07.004

Figure 2. LGP2 is required for protection against WNV infection.

Figure 2

(A) Survival of WT (n=26) and Dhx58−/− (n=17) adult mice infected subcutaneously with 100 PFU of WNV-TX. Viral burden analysis from WT and Dhx58−/− infected mice in the (B) pDLN, (C) spleen, and (D) kidney (also analyzed Ips-1−/− mice) (E) IFN-β, (F) IFIT1, and (G) IFIT2 expression in the pDLN were determined by qRT-PCR. (H) Immunoblot analysis of spleens from WT and Dhx58−/− mock infected (M) and WNV-TX infected mice at the indicated days post-infection. (I) Serum type I IFN measured by an L929 bioassay. Dotted line represents the limit of assay sensitivity. Graphs show the mean +/− standard deviation of triplicate biological samples from three independent experiments.