Table 2.
rs11540761 and rs1048801 allele frequencies in systemic lupus erythematosus patients and controls, stratified by ancestral background and high versus low serum type I IFN activity
Subject group | rs11540761 MAF | High versus low IFN | Meta-analysis high versus low IFN | rs1048801 MAF | High versus low IFN | Meta-analysis high versus low IFN |
---|---|---|---|---|---|---|
EA Controls n=116 | 0.181 | – | – | 0.431 | – | – |
EA cases n=132 | 0.155 | – | – | 0.333 | – | – |
High IFN EA cases n=56 | 0.212 | p=0.031 OR=2.05 | p=0.016 | 0.384 | p=0.13 OR=1.48 | p=0.14 |
Low IFN EA cases n=76 | 0.116 | 0.296 | ||||
High IFN HA cases n=44 | 0.350 | p=0.052 OR=2.26 | 0.432 | p=0.25 OR=1.46 | ||
Low IFN HA cases n=35 | 0.192 | 0.343 |
EA, European-American ancestry; HA, Hispanic-American ancestry; MAF, minor allele frequency.