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. Author manuscript; available in PMC: 2014 Feb 3.

Published in final edited form as: Nat Genet. 2013 Jun 2;45(7):799–803. doi: 10.1038/ng.2645

Regional plots of association results, recombination hotspots and linkage disequilibrium for the (a) 6p21.31:34,046,381–34,243,213 and (b) 2p25.2:6,280,533–6,473,384 osteosarcoma susceptibility loci. Association results from a trend test in –log10P values (y axis, left; gray diamonds, combined GWAS result; sky blue diamonds, TaqMan result; red diamonds, combined result) of the SNPs are shown according to their chromosomal positions (x axis). Linkage disequilibrium structure based on controls (n=2,703) was visualized by snp.plotter software. The line graph shows likelihood ratio statistics (y axis, right) for recombination hotspot by SequenceLDhot software and 5 different colors represent 5 tests of 100 controls without resampling. Physical locations are based on NCBI human genome build 36. Gene annotation was based on the NCBI RefSeq genes from the UCSC Genome Browser.

Regional plots of association results, recombination hotspots and linkage disequilibrium for the (a) 6p21.31:34,046,381–34,243,213 and (b) 2p25.2:6,280,533–6,473,384 osteosarcoma susceptibility loci. Association results from a trend test in –log10P values (y axis, left; gray diamonds, combined GWAS result; sky blue diamonds, TaqMan result; red diamonds, combined result) of the SNPs are shown according to their chromosomal positions (x axis). Linkage disequilibrium structure based on controls (n=2,703) was visualized by snp.plotter software. The line graph shows likelihood ratio statistics (y axis, right) for recombination hotspot by SequenceLDhot software and 5 different colors represent 5 tests of 100 controls without resampling. Physical locations are based on NCBI human genome build 36. Gene annotation was based on the NCBI RefSeq genes from the UCSC Genome Browser.