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. Author manuscript; available in PMC: 2014 Nov 1.
Published in final edited form as: FEBS Lett. 2013 Sep 13;587(21):3456–3463. doi: 10.1016/j.febslet.2013.08.034

Figure 6. Schema of the proposed impact of coronary heart disease on miRNA-mediated intercellular communication.

Figure 6

CHD impacts miRNA-mediated intercellular communication via three mechanisms: i) by decreasing miRNA loading of MPs, ii) by altering Del-1 binding to MPs, and iii) by decreasing MP uptake. Altered miRNA profile of MPs and decreased miRNA content in MPs suggests CHD-associated abnormalities within the donor cell. Impaired MP uptake is likely to impact the behavior and function of the target cell.