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. Author manuscript; available in PMC: 2014 Oct 10.
Published in final edited form as: Cell. 2013 Oct 10;155(2):462–477. doi: 10.1016/j.cell.2013.09.034

Figure 3. Somatic alterations of the EGFR locus.

Figure 3

(A) EGFR protein domain structure with somatic mutations summarized from 291 GBMs with exome sequencing and transcript alterations identified across 164 GBMs with RNA sequencing.

(B) EGFR alterations are summarized by transcript prevalence in 164 GBMs with RNA sequencing. Red, top: focal amplification or regional gain inferred from DNA copy number. Blue: Prevalence of sequencing reads with EGFR point mutation. Green: prevalence of reads with aberrant exon-exon junctions (e.g., 1E–8S is a junction spanning from the end of exon 1 to the start of exon 8, consistent with EGFRvIII mutation). Black: EGFR fusion transcript detected (see rearrangements). See related SI Figure S4 for comparison of EGFR mutations in DNA and RNA and for a summary of EGFR rearrangements.