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. Author manuscript; available in PMC: 2014 Feb 3.
Published in final edited form as: Arch Neurol. 2012 Oct;69(10):1303–1309. doi: 10.1001/archneurol.2012.465

Figure 3.

Figure 3

Statins reduce interferon-beta therapy induction of serum type 1 interferon activity in 14 stable patients with relapsing-remitting multiple sclerosis. A, In vivo Rebif kinetics after a 3-day washout. B and C, Statin add-on therapy blocks interferon-beta therapy induction of serum interferon-α/β activity in 14 patients with relapsing-remitting multiple sclerosis. Serum samples were obtained at 8 am after statin washout or long-term statin alone and then exactly 4 hours after interferon-beta injections or high-dose statins plus 4 hours of interferon-beta therapy. *P <.001 vs interferon alone (paired t test). Error bars indicate SEM.