Table 3.

a: Caregiver outcome measures by patient week 12 remission status for each week of assessment (Scores are medians with 95% CI*).
					Caregiver Outcome
	Depression (BDI) **		Distress (NPI- Distress)***		Burden (ZBI) †		Quality of Life††
							Physical (SF-12- Physical)		Mental (SF-12-Mental)
Time	Remission	No remission	Remission	No remission	Remission	No remission	Remission	No remission	Remission	No remission
Baseline	5	6	15	19	21	24	54	49	55	52
	(2.5, 7)	(5, 8)	(11.5, 18)	(17, 21)	(14, 27.5)	(21, 7.5)	(50, 58.5)	(44, 54)	(52, 59)	(49, 55)
Week 8	3.5	7	5	13	20	25	52	48	57.5	53
	(1, 6)	(4, 9.5)	(2, 8)	(11, 15)	(12, 28)	(19.5, 31)	(45.5, 59)	(45, 51.5)	(54, 61)	(50.5, 56)
Week 16	5	6	5	11	20	24	51.5	46	56	51
	(2, 7)	(4, 8)	(3, 7)	(8.5, 13)	(12.5, 27)	(20, 28)	(47, 56)	(42.5, 50)	(52, 60)	(48.5, 54)
Week 24	4	6	5	12.5	20	25	50	49	55	53
	(0.5, 8)	(4.5, 7.5)	(2, 8)	(10, 15)	(13, 26.5)	(20, 29.5)	(44, 55.5)	(45, 53.5)	(52, 58.5)	(50, 56)

b. Regression coefficients (95% CI) for the associations between week 12 patient remission status (remitter vs. non-remitter) and caregiver outcomes at baseline and week 24*
					Caregiver Outcome
	Depression (BDI) **		Distress (NPI- Distress)***		Burden (ZBI) †		Quality of Life††
Model variable							Physical (SF-12- Physical)		Mental (SF-12-Mental)
	Coefficient	p- value	Coefficient	p- value	Coefficient	p- value	Coefficient	p- value	Coefficient	p- value
Baseline scores for	1.50	<0.01	4.58	<0.01	23.41	<0.01	46.14	<0.01	50.88	<0.01
caregivers of non-remitters	(1.01, 1.99)		(3.97, 5.19)		(16.58, 30.23)		(40.54, 51.74)		(45.87, 55.89)
Difference in baseline scores	−0.27	0.14	−0.48	0.04	−3.74	0.16	4.16	0.04	2.79	0.19
between caregiver groups (remitters - non-remitters)	(−0.64, 0.09)		(−0.94, −0.01)		(−8.98, 1.50)		(0.20, 8.12)		(−1.40, 6.98)
Linear slope over 24 weeks	−0.01	0.13	−0.18	<0.01	−0.04	0.43	−0.01	0.82	0.03	0.63
(change in scores) for caregivers of non-remitters	(−0.01, 0.00)		(−0.24, −0.12)		(−0.13, 0.05)		(−0.11, 0.09)		(−0.08, 0.14)
Difference in slopes	0.00	0.72	−0.20	<0.01	−0.03	0.72	−0.10	0.31	−0.08	0.45
between groups (remitters - non-remitters)	(−0.02, 0.01)		(−0.32, −0.07)		(−0.23, 0.16)		(−0.30, 0.10)		(−0.27, 0.12)

^*CI: Confidence Interval; Standard errors for medians calculated by bootstrapping. The results from all five imputations were combined.

^**Caregiver depression as rated by the Beck Depression Inventory; higher scores indicate more reported depressive symptoms.

^***Caregiver distress as rated by the Neuropsychiatric Inventory; higher scores indicate greater reported caregiver distress.

^†Caregiver burden as rated by the Zarit burden interview; higher scores indicate more reported burden of caregiving.

^††Caregiver quality of life as rated by the SF-12; higher scores indicate higher reported quality of life. Physical is the SF-12 Physical component score (PCS) and Mental is the SF-12 Mental component score (MCS).

^*CI: Confidence Interval; Estimation by mixed model regression with random intercept and slope for participant; p-values are from fixed effects t-tests. Models controlled for years of education of the patient.

^**Caregiver depression as rated by the Beck Depression Inventory; higher scores indicate more reported depressive symptoms. A log transformation of the outcome was used for analysis.

^***Caregiver distress as rated by the Neuropsychiatric Inventory; higher scores indicate greater reported caregiver distress. Square root transformations of the outcome and the time predictor were used for analysis.

^†Caregiver burden as rated by the Zarit burden questionnaire; higher scores indicate more reported burden of caregiving.

^††Caregiver quality of life as rated by the SF-12; higher scores indicate higher reported quality of life.