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. Author manuscript; available in PMC: 2014 Feb 3.
Published in final edited form as: J Cereb Blood Flow Metab. 2009 Mar 25;29(6):1084–1098. doi: 10.1038/jcbfm.2009.32

Figure 2.

Figure 2

Changes in paracellular permeability to 14C-sucrose during peripheral inflammatory pain in the presence and absence of SB431542, a selective ALK5 inhibitor. Graph shows the percent of radioactivity detected in the brain as compared with that in the perfusate (% RBr) for the five treatment groups 3 h after injection of 3% λ-carrageenan or 0.9% saline into the plantar surface of the right hind paw. SB431542 (1.5 mg/kg) or vehicle (100% dimethyl sulfoxide) were injected i.p. 30 mins before footpad injection. Results are expressed as mean ± s.d. of six animals per treatment group.