Table 1.
Function Clusters (Top Three) According to the Differentially Expressed Genes in CD4+ and CD8+ T Cells
| GO-term | Term | Count | Genes (part) | |
|---|---|---|---|---|
| CD4+ | ||||
| Acute | 0042127 | Regulation of cell proliferation | 45 | BRCA1, ITGB1, GF1R, |
| 0008284 | Positive regulation of cell proliferation | 29 | ITBG1, IGF1R, ENDN3 | |
| 0009719 | Response to endogenous stimulus | 28 | BRCA1, IGF1R, CAV1 | |
| 0006955 | Immune response | 35 | IF144, IFI44L, TNFSF11 | |
| Chronic | 0006952 | Defense response | 31 | ITGB1, IFIH1, KYNU |
| 0007626 | Locomotor behavior | 17 | SERPIND, ANKH, CCRL2 | |
| 0042592 | Homeostatic process | 23 | ITGB1, IL1A, TNNI3 | |
| Nonprogressor | 0007267 | Cell–cell signaling | 22 | GAL, GLRB, SYT1 |
| 0042127 | Regulation of cell proliferation | 20 | GAL, IL1A, FLT1 | |
| CD8+ | ||||
| Acute | 0007049 | Cell cycle | 81 | BRCA1, ITBG1, NCAPG |
| 0022402 | Cell cycle process | 66 | BRCA1, ITBG1, NCAPG | |
| 0000278 | Mitotic cell cycle | 57 | BRCA1, ITBG1, NCAPG | |
| 0009615 | Response to virus | 17 | IF144,IFIH1, BST2 | |
| Chronic | 0006955 | Immune response | 33 | IF144L, IF144, IFIH1 |
| 0051270 | Regulation of cell motion | 14 | IGF1R, ACTN1, | |
| 0006955 | Immune response | 26 | CSF3, IGF1R, LST1 | |
| Nonprogressor | 0042127 | Regulation of cell proliferation | 26 | CSF3, IGF1R, LST1 |
| 0043067 | Regulation of programmed cell death | 25 | TOP2A, IGF1R, OP2 | |