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. 2014 Jan 9;111(4):1545–1550. doi: 10.1073/pnas.1315153111

Fig. 6.

Fig. 6.

Bone histomorphometric and serum analyses in clodronate liposome-treated mice. Histomorphometric analyses of tibiae using the experimental design in Fig. 5A. (A) Representative images with histomorphometric analyses. (B) Osteoclast numbers per bone volume (N.OC/BS) measured in TRAP-stained sections. *P < 0.05; **P < 0.01 versus vehicle-treated PBS. (C and D) Serum (C) P1NP (nanograms per milliliter) and (D) TRAP5b (units per liter) measured at 4 and 6 wk. #P < 0.05 versus vehicle-treated CLOD; δP < 0.05 versus vehicle in each group at 4 wk; ψP < 0.05 versus vehicle in each group at 6 wk. Data are mean ± SEM of two independent experiments. n = 10–15 per group. CLOD, clodronate liposome; PBS, PBS liposome.

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