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. 2014 Jan 13;111(4):E435–E444. doi: 10.1073/pnas.1311121111

Fig. 2.

Fig. 2.

Inhibition of lipogenesis is not a mechanism of AICAR and metformin’s antiproliferative action. Proliferation of FASN-silenced (A) and ACC-silenced (B) T98G and U87EGFRvIII glioma cells treated with AICAR and metformin. nt, nontarget. Immunoblot with FASN (A, Inset) and ACC (B, Inset) antibodies. nt, nontarget shRNA. *P ≤ 0.005. (C) Proliferation of glioma cells in the presence of lipogenesis inhibitors [C75 (10 µg/mL) and atorvastatin (1 µM)]. Data shown is representative of two to four independent experiments. Error bars in A–C represent mean ± SD.