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. 2004 Apr 1;23(7):1483–1493. doi: 10.1038/sj.emboj.7600150

Figure 4.

Figure 4

Minor groove interactions are lost in furan-containing DNA. (A) Minor groove interactions in the active site of ternary complex (1IG9; Franklin et al, 2001). Hydrogen bonds are shown as dashed red lines. For clarity only the bases of the primer strand are shown. (B) Pol1, in the same orientation as the ternary complex in (A). All minor groove interactions seen in the ternary complex are lost. (C) Pol2, in the same orientation as in (A) and (B). The DNA shifts further away from the palm domain.