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. 2014 Jan 13;111(4):1403–1408. doi: 10.1073/pnas.1311705111

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Fig. 2. — Inhibition of Notch signaling following amputation injury prevents cardiac regeneration. (A–D) Inhibition of Notch signaling impairs cardiac regeneration. Representative cardiac sections from heat shocked control (A and C) and Tg(hsp70:DN-MAML) (B and D) animals 30 dpa evaluated by AFOG staining (A and B) or immunofluorescence (C and D) for the myocardial marker TPM. Whereas heat shocked control animals robustly regenerated myocardium (asterisks in A and C), Tg(hsp70:DN-MAML) hearts failed to regenerate new myocardium (arrowheads in B and D) instead showing evidence of residual fibrin (red in B) and collagen deposition (blue in B). Cardiac regeneration failed in 0 of 24 heat shocked control animals and 34 of 35 heat shocked Tg(hsp70:DN-MAML) animals.