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H2S up-regulates antioxidant- and survival-related genes. H2S translocates Nrf2 into the nucleus to activate antioxidant-related genes such as HO-1 and Trx. It also activates PKCɛ and STAT3 to translocate dimerized STAT3 to the nucleus, which then activates survival-related genes such as HSP, Bcl2, and Bcl-xL. RPS3, ribosomal protein S3.
