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Antiapoptotic action of H2S. TNFα activates the transcription of CSE gene to increase the levels of CSE. H2S produced by CSE sulfhydrates NF-kB, which leads to the translocation of NF-kB into the nucleus to activate the transcription of antiapoptotic genes. CSE, cystathionine γ-lyase; Nrf2, nuclear factor erythroid 2-related factor 2; STAT3, signal transducers and activators of transcription 3;TNF-α, tumor necrosis factor-α.
