FIG 1.

Miltefosine susceptibility of the WT and an experimentally selected resistant strain of L. panamensis. The dose response to HePC of WT and experimentally selected miltefosine-resistant controls are presented (means and standard errors of the means [SEM] from three independent experiments) for promastigotes and amastigotes. Survival is presented as the percent survival of promastigotes or intracellular amastigotes compared to drug-free control at each drug concentration. S, sensitive; R, resistant.