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Predicted total terbinafine concentration-time profiles in plasma over the first 7 days of treatment using the PBPK model. The dashed line represents terbinafine dosed at 250 mg once daily (q24h) in each panel, with the solid line representing 250 mg every 12 h (q12h) (A), 250 mg every 8 h (q8h) (B), 500 mg q24h (C), and 500 mg q12h (D).
