TABLE 1.
Pharmacokinetic parameters for predicted total and unbound terbinafine plasma concentrations on day 1, day 7, and day 28 for standard and high-dose terbinafine regimens
| Parameter | Day of therapy | Values [total (unbound)] for indicated dose regimena |
||||
|---|---|---|---|---|---|---|
| 250 mg q24h | 250 mg q12h | 500 mg q24h | 250 mg q8h | 500 mg q12h | ||
| AUC0–24 (mg · h/liter) | 1 | 5.40 (0.0540) | 10.4 (0.104) | 10.8 (0.108) | 15.2 (0.152) | 20.6 (0.206) |
| 7 | 8.30 (0.0830) | 16.4 (0.164) | 16.6 (0.166) | 24.6 (0.246) | 32.9 (0.329) | |
| 28 | 9.73 (0.0973) | 19.4 (0.194) | 19.5 (0.195) | 29.1 (0.291) | 38.9 (0.389) | |
| Cmax (mg/liter) | 1 | 1.32 (0.0132) | 1.35 (0.0135) | 2.20 (0.0220) | 1.39 (0.0139) | 2.24 (0.0224) |
| 7 | 1.46 (0.0146) | 1.61 (0.0161) | 2.46 (0.0246) | 1.80 (0.0180) | 2.78 (0.0278) | |
| 28 | 1.52 (0.0152) | 1.74 (0.0174) | 2.59 (0.0259) | 1.99 (0.0199) | 3.04 (0.0304) | |
| Cmin (mg/liter) | 1 | 0.0332 (0.000332) | 0.0659 (0.000659) | 0.0666 (0.000666) | 0.162 (0.00162) | 0.147 (0.00147) |
| 7 | 0.143 (0.00143) | 0.308 (0.00308) | 0.288 (0.00288) | 0.537 (0.00537) | 0.632 (0.00632) | |
| 28 | 0.198 (0.00198) | 0.427 (0.00427) | 0.397 (0.00397) | 0.722 (0.00722) | 0.872 (0.00872) | |
a
For dose regimens where more than one dose is administered in a 24-h period, Cmax and Cmin values for each day of therapy represent the average of the Cmax and Cmin values for each dosing interval in the corresponding 24-h period.